CJC-1295 with DAC and Modified GRF (1-29), often sold as "CJC-1295 no DAC", share the same 29-residue GRF (1-29) backbone. The difference is one added C-terminal lysine carrying a maleimidopropionyl group, the drug affinity complex (DAC). The two are frequently confused in vendor naming.
| Property | CJC-1295 (with DAC) | CJC-1295 no DAC (Modified GRF 1-29) |
|---|---|---|
| Class | Synthetic GRF (1-29) analogue with an added C-terminal lysine bearing a maleimidopropionyl (DAC) group | Synthetic 29-amino-acid analogue of human growth hormone-releasing factor, hGRF (1-29) |
| Molecular formula | C165H269N47O46 [1] | C152H252N44O42 [2] |
| Molecular weight (g/mol) | 3647.2 [1] | 3367.9 [2] |
| CAS number | 446262-90-4 [1] | 863288-34-0 |
| PubChem CID | 91971820 [1] | 56841945 [2] |
| Sequence | Y-(D-Ala)-DAIFTQSYRKVLAQLSARKLLQDILSR-K(maleimidopropionyl)-NH2 [1] | Y-(D-Ala)-DAIFTQSYRKVLAQLSARKLLQDILSR-NH2 [2] |
| FDA | Not approved; compounding nomination withdrawn [3][4] | Not approved; FDA's entry names "CJC-1295" without separating the two forms [3] |
| Health Canada | "CJC-1295" named among unauthorized peptide drugs seized by Health Canada [5] | Same entry; the advisory does not separate the two forms [5] |
| WADA 2026 | Prohibited at all times, S2.2.4 GHRH analogues [6] | Prohibited at all times, S2.2.4 GHRH analogues [6] |
| Supplied by Ageless Peptides | No | Yes |
CJC-1295 (with DAC)
CJC-1295 with DAC is a long-acting synthetic analogue of human growth hormone-releasing factor hGRF (1-29) and a GHRH-receptor agonist. It is not FDA-approved and has no identified EMA, MHRA or TGA marketing authorization. FDA lists CJC-1295 among withdrawn compounding nominations and states: "FDA has identified serious adverse events associated with CJC-1295 including increased heart rate and systemic vasodilatory reaction. Available clinical data are limited." [3] Ageless Peptides does not supply this form.
CJC-1295 no DAC (Modified GRF 1-29)
Modified GRF (1-29) is a synthetic 29-amino-acid analogue of human growth hormone-releasing factor, also called Mod GRF (1-29) and commonly, but misleadingly, called CJC-1295 no DAC. It is not FDA-approved, and no EMA, MHRA or TGA marketing authorization was identified in the reviewed evidence. FDA and Health Canada materials name "CJC-1295" without distinguishing DAC and non-DAC forms. [3][5]
Full reference: CJC-1295 no DAC research reference
Lot documentation
Each lot of each compound has its own Certificate of Analysis. Compare compounds only against the COA for the exact lot used.
Research use only
Ageless Peptides supplies these compounds as lyophilized material for laboratory research only. They are not drugs, foods, cosmetics or dietary supplements, are not for human or veterinary use, and nothing on this page is medical advice or a statement of safety or effectiveness for any human or veterinary use.
